langerhans cell histiocytosis

Langerhans Cell Histiocytosis (LCH) presents a complex puzzle in modern medicine. This rare multisystem disease, first identified by German physician Paul Langerhans in 1865, involves a pathological proliferation of Langerhans cells - part of the monocyte-macrophage lineage. LCH's clinical spectrum is wide and heterogeneous, making diagnosis and management particularly challenging